Screening for MODY is not a routine practice for diabetes classification despite the fact that there is significant clinical overlap between MODY and type 1 and 2 diabetes. The conceptual framework for the cost analysis is depicted in Fig.
This article has been cited by other articles in PMC. Costs were expressed in USD.
Additional features of MODY depend upon its molecular genetic basis. MODY is classically defined as autosomal dominant, non—insulin dependent diabetes with diagnosis typically before 25 years of age 2. However, these tests are not yet in routine clinical practice in the U.
The conceptual framework for the cost analysis is depicted in Fig. The first-line therapy for HNF1A- and HNF4A-MODY is sulfonylurea pills, which result in stable or improved glycemic control and improved quality of life related to diabetes care compared with insulin or metformin therapy 4 — 7. Apart from clinical features, there are established biomarkers to aid in patient selection for genetic testing, such as high-sensitivity CRP or urinary C-peptide—to—creatinine ratio. Received Feb 19; Accepted Sep 3.
This request will be reviewed. Assessing the economic value of genetic testing for these MODY subtypes in diabetes may clarify practices for selection of patients for testing and inform policy decisions regarding medical insurance coverage for genetic testing costs. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
However, these tests are not yet in routine clinical practice in the U. Feel free to provide more information By clicking on "Submit" below, you are certifying the following statements: After all necessary information is provided, of course:
Posted by: Fezragore | on October 2, 2012
Assessing the economic value of genetic testing for these MODY subtypes in diabetes may clarify practices for selection of patients for testing and inform policy decisions regarding medical insurance coverage for genetic testing costs. Thus, many cases of MODY are being missed.
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