Outcomes Retinopathy, which was measured objectively with stereoscopic fundus photography and graded with standardized methods by a central reading center 13 , was the primary outcome used for power and sample-size calculations. At the end of DCCT, after an average of 6. DCCT Interventions and Metabolic Goals The clinical goals for both treatment groups included absence of frequent symptoms of hyperglycemia or frequent or severe hypoglycemia, defined as requiring assistance from another person.
Although in most long-term studies loss to follow-up may compromise the integrity and interpretation of study results, the follow-up in DCCT and subsequently in EDIC has been virtually complete. EDIC showed a durable effect of initial assigned therapies despite a loss of the glycemic separation metabolic memory and demonstrated that the reduction in early-stage complications during the DCCT translated into substantial reductions in severe complications and CVD. The subjects and DCCT clinic staff chose which modality to use.
Briefly, in order to address the primary prevention and secondary intervention questions, the following eligibility criteria were used: At the start of the DCCT, participants had type 1 diabetes for at least 1 year but no longer than 15 years, and had no or only early signs of diabetic eye or kidney diseases. Outcomes Retinopathy, which was measured objectively with stereoscopic fundus photography and graded with standardized methods by a central reading center 13 , was the primary outcome used for power and sample-size calculations.
INT utilized three or more daily insulin injections or insulin pump therapy guided by self-monitored glucose. The study involved 1, volunteers ages 13 to 39, and took place in 29 medical centers in the United States and Canada. This article has been cited by other articles in PMC. The treatment strategies employed produced statistically significant and clinically meaningful differences in HbA1c concentrations and blood glucose profiles between the experimental- and standard-group subjects for both adults and adolescents.
Related Studies United Kingdom Prospective Diabetes Study - Researchers showed that controlling blood glucose levels in people with type 2 diabetes reduced the risk of diabetic eye disease and diabetic kidney disease. Participants took insulin 3 or more times per day by injection or an insulin pump and self-monitored their blood glucose levels four or more times a day. Only the quarterly results were used for study data.
Briefly, in order to address the primary prevention and secondary intervention questions, the following eligibility criteria were used: The full-scale, long-term trial therefore has been initiated. Another study is looking at the small amount of insulin that some people with type 1 diabetes continue to make and whether this improves health.
Posted by: Gagar | on October 2, 2012
Microvascular disease and peripheral neuropathy resulted in blindness, kidney failure, and amputations 3 ; and macrovascular disease, exacerbated by renal dysfunction and autonomic neuropathy, increased the risk for myocardial infarctions and stroke to levels that were fold or more than in the age-matched nondiabetic population 2 , 3. Similarly important outcomes were nephropathy and retinopathy.
The DCCT ended after 10 years in —a year earlier than planned—when the study proved that participants who kept their blood glucose levels close to normal greatly lowered their chances of having eye, kidney, and nerve disease. When EDIC began, participants who used conventional treatment were taught about intensive treatment, and received follow-up care from their own health care team. The pathoetiology of the microvascular complications was vigorously debated during the midth century 4 — 6.
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